CRHS is based in Wellington and serves the areas in the lower half of the North Island. The areas covered by Capital and Coast DHB, Hutt Valley DHB, Wairarapa DHB, MidCentral DHB, Whanganui DHB and Hawke's Bay DHB. 

Most students admitted to CRHS remain on their regular school roll. 

The aim of the Central Regional Health School is to maintain the education of students (year 0 to year 13) when their physical or mental health needs mean they are unable to attend their regular school. CRHS also provides the education programme for students at Te Au rere a te Tonga in Palmerston North (formerly the Lower North Youth Justice residence).